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Ankylosing Spondylitis !!

Here is the detail of a disease “Ankylosing Spondylitis”,whats is this disease,How it is caused,What are the symptoms of Ankylosing spondylitis,How it is diagnosed and whats is its Treatment?

Ankylosing Spondylitis:







It is a type of Arthritis which causes the Long lasting Inflammation of the Joints of Spine.

It is a systemic rheumatic disease and one of Spondyloarthropathies.

It causes the Complete Fusion of Spine leading to a condition called “Bamboo Spine”.


Age:Mostly in yound aged between 18-30 Years.

Gender:Men are more affected then Female.


Cause of Ankylosing spondylitis is Unknown but it invloves Genetic and Enviromental Factors.Its underlying mechanism is Auto-immune or auto-inflammatory.

People affected by this disease have

  • HLA-B27 antigen
  • Tumor necrosis factor
  • Interleukin-1 (IL-1)

Symptoms of Ankylosing Spondylitis:

  1. Mild to Severe Back pain                 
  2. Chronic Dull Buttock Pain             
  3. Pain is Severe at Rest
  4. Pain decreases by Activity
  5. Stiffness
  6. Inflammation
  7. Loss of Spinal Mobility
  8. Limitation of Anterior and Lateral Flexion of Lumbar spine
  9. Limitation of Lumbar extension
  10. Weight loss
  11. Fever
  12. Fatigue
  13. Decreased motion in Neck and Low back
  14. Kyphosis
  15. Chest Expansion             
  16. Iridocyclitis (inflammation of the white of the eye )      
  17. Eye Pain
  18. Photophobia
  19. Aortitis
  20. Apical lung fibrosis            
  21. Ectasia of the sacral nerve root sheaths
  22. Onycholysis (Lifting of the Nails)                 



  • NSAIDS (Ibuprofen,Naproxen)
  • Opioids
  • Disease-modifying anti rheumatic drugs (DMARDs)
  • Tumor Necrosis Factor-alpha (TNFα) blockers
  • Anti-interleukin-6 inhibitors
  • Interleukin-17A inhibitor

Physical Therapy:

  • TENS
  • Thermotherapy
  • Low intensity Aerobic Exercise
  • Proprioceptive neuromuscular facilitation (PNF)
  • Exercise Program (Either Home plan or Supervised)
  • Group Exercise


  • Joint Replacement
  • Surgical Correction of joints


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